Antibody Engineering

Genebeyond® offers proprietary monoclonal antibody (mAb) technology including antibody library design, construction and selection, various state-of-the-art (phage, yeast and mammalian cell) display platforms for mAb affinity maturation, antibody humanization. Our bispecific antibody (BsAb) services include design, expression and characterization of BiTE (Bispecific T-cell Engager), DART (Dual affinity retargeting), DVD-Ig (dual-variable-domain immunoglobulin), DNL (Dock-and-Lock), KIH (Knobs-into-Holes), CrossMab, Triomab, Tandem scFv-Fc, …

Genebeyond offers mammalian cell expression platforms to meet the high-quality demands on recombinant antibody including full-length IgG, scFv, VHH, VH, Fab, non-IgG scaffold antibodies and Fc-fusion proteins. We provide services of plasmid design and construction, antibody transient expression and stable cell line development of CHO and HEK293 cells. Genebeyond also provides alternate suite of recombinant antibody services with E. coli, insect cell antibody expression systems for a variety of downstream applications such as HTS, activity and functional assays, antibody interaction studies and more.

Our antibody engineering service includes:

  • Monoclonal antibody (mAb) production
  • Bispecific antibody (BsAb) design and production
  • Antibody expression and purification
  • Antibody library design and screening
  • Antibody affinity maturation
  • Antibody humanization
  • Antibody drug conjugation
  • Fc fusion protein design and production